Success of ampicillin plus ceftriaxone rescue therapy for a relapse of Enterococcus faecalis native-valve endocarditis and in vitro data on double beta-lactam activity

Jose M Miro; Carlos Cervera; Cristina Garcia-de-la-Maria; Ana Del Rio; Yolanda Armero; Carlos A Mestres; Jose M Grau; Francesc Marco; Asuncion Moreno

doi:10.1080/00365540802398945

Success of ampicillin plus ceftriaxone rescue therapy for a relapse of Enterococcus faecalis native-valve endocarditis and in vitro data on double beta-lactam activity

Scand J Infect Dis. 2008;40(11-12):968-72. doi: 10.1080/00365540802398945.

Authors

Jose M Miro¹, Carlos Cervera, Cristina Garcia-de-la-Maria, Ana Del Rio, Yolanda Armero, Carlos A Mestres, Jose M Grau, Francesc Marco, Asuncion Moreno

Affiliation

¹ Infectious Diseases Service, Hospital Clinic, Helios Building, Desk no. 26, Villarroel 170, 08036 Barcelona, Spain. jmmiro@ub.edu

PMID: 18767002
DOI: 10.1080/00365540802398945

Abstract

We report a patient with Enterococcus faecalis native-valve endocarditis who relapsed after 4 weeks of treatment with ampicillin plus gentamicin. The relapse was cured with ampicillin plus ceftriaxone, which was introduced after gentamicin-induced acute renal failure. This double beta-lactam combination showed a bactericidal effect in time-killing curve studies.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Ampicillin / administration & dosage*
Ampicillin / therapeutic use
Anti-Bacterial Agents / administration & dosage
Anti-Bacterial Agents / therapeutic use
Ceftriaxone / administration & dosage*
Ceftriaxone / therapeutic use
Dose-Response Relationship, Drug
Drug Therapy, Combination
Endocarditis, Bacterial / drug therapy*
Endocarditis, Bacterial / microbiology
Enterococcus faecalis* / drug effects
Female
Gram-Positive Bacterial Infections / drug therapy*
Gram-Positive Bacterial Infections / microbiology
Humans
Microbial Sensitivity Tests
beta-Lactam Resistance

Substances

Anti-Bacterial Agents
Ceftriaxone
Ampicillin