Abstract
Frataxin is a conserved mitochondrial protein, almost universally present in prokaryotes and eukaryotes, where it is implicated in Fe-S cluster assembly and several other processes. Here we show that frataxins from the diatom Thalassiosira pseudonana and the plant Arabidopsis thaliana are efficiently targeted and processed in the mitochondrion of the evolutionary distant excavate kinetoplastid flagellate Trypanosoma brucei. Moreover, both heterologous frataxins are able to rescue a lethal deficiency for T. brucei frataxin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Arabidopsis / genetics
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Arabidopsis / metabolism*
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Arabidopsis Proteins / genetics
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Arabidopsis Proteins / metabolism*
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Diatoms / genetics
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Diatoms / metabolism*
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Frataxin
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Iron-Binding Proteins / chemistry
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Iron-Binding Proteins / genetics
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Iron-Binding Proteins / metabolism*
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Iron-Sulfur Proteins / metabolism
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Mitochondria / metabolism*
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Molecular Sequence Data
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Trypanosoma brucei brucei / genetics
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Trypanosoma brucei brucei / metabolism*
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Trypanosoma brucei brucei / ultrastructure
Substances
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Arabidopsis Proteins
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Iron-Binding Proteins
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Iron-Sulfur Proteins