Multicomponent synthesis of benzoxazinones via tandem Ugi/Mitsunobu reactions: an unexpected cine-substitution

Luca Banfi; Andrea Basso; Giuseppe Guanti; Paulina Lecinska; Renata Riva

doi:10.1007/s11030-008-9087-7

Multicomponent synthesis of benzoxazinones via tandem Ugi/Mitsunobu reactions: an unexpected cine-substitution

Mol Divers. 2008 Aug-Nov;12(3-4):187-90. doi: 10.1007/s11030-008-9087-7. Epub 2008 Sep 2.

Authors

Luca Banfi¹, Andrea Basso, Giuseppe Guanti, Paulina Lecinska, Renata Riva

Affiliation

¹ Department of Chemistry and Industrial Chemistry, University of Genova, via Dodecaneso 31, 16146, Genova, Italy. banfi@chimica.unige.it

PMID: 18763045
DOI: 10.1007/s11030-008-9087-7

Abstract

A short (2 steps) synthesis of diverse benzoxazinones by coupling the Ugi multicomponent reaction with an intramolecular Mitsunobu substitution is reported. The cyclization step proceeds via an unexpected cine substitution.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzoxazines / chemical synthesis*
Benzoxazines / chemistry
Methods
Models, Chemical
Molecular Structure

Substances

Benzoxazines