Abstract
Transient receptor potential (TRP) channels respond to diverse external stimuli and convert them into intracellular calcium signals. Recent evidence shows that TRPV4, one of the vanilloid subfamily, plays a key role in mechanosensation in bone. Here I summarize the current knowledge on possible functions of TRP channels.
MeSH terms
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Animals
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Bone Density
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Bone and Bones / cytology
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Bone and Bones / metabolism
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Calcium Signaling / genetics
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Calcium Signaling / physiology
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Humans
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Mechanotransduction, Cellular / genetics
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Mechanotransduction, Cellular / physiology
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Mice
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Osteogenesis / genetics
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Osteogenesis / physiology
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Stress, Mechanical
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TRPC Cation Channels / physiology*
Substances
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TRPC Cation Channels
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TRPC4 ion channel