[TRP channels and mechanical stress]

Clin Calcium. 2008 Sep;18(9):1304-11.
[Article in Japanese]

Abstract

Transient receptor potential (TRP) channels respond to diverse external stimuli and convert them into intracellular calcium signals. Recent evidence shows that TRPV4, one of the vanilloid subfamily, plays a key role in mechanosensation in bone. Here I summarize the current knowledge on possible functions of TRP channels.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Bone Density
  • Bone and Bones / cytology
  • Bone and Bones / metabolism
  • Calcium Signaling / genetics
  • Calcium Signaling / physiology
  • Humans
  • Mechanotransduction, Cellular / genetics
  • Mechanotransduction, Cellular / physiology
  • Mice
  • Osteogenesis / genetics
  • Osteogenesis / physiology
  • Stress, Mechanical
  • TRPC Cation Channels / physiology*

Substances

  • TRPC Cation Channels
  • TRPC4 ion channel