Abstract
Several steroidal 6,6-ethylene-15,16-methylene 17-spirolactones were synthesized to find new progestogens that exhibit both progestational and antimineralocorticoidal activities. The influence of substituents in the 10- and 13-position of the steroidal framework on both properties was investigated. It was found that only compound 12, carrying methyl groups at the 10- and 13-positions, possesses high progestational and antimineralocorticoidal activity.
MeSH terms
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Adrenalectomy
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Aldosterone / pharmacology
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Animals
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Chemical Phenomena
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Chemistry
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Endometrium / drug effects
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Endometrium / growth & development
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Female
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Male
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Mineralocorticoid Receptor Antagonists / chemical synthesis*
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Mineralocorticoid Receptor Antagonists / metabolism
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Mineralocorticoid Receptor Antagonists / pharmacology
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Molecular Structure
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Potassium / urine
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Pregnancy
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Pregnancy Maintenance / drug effects
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Rabbits
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Rats
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Rats, Inbred Strains
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Receptors, Progesterone / metabolism
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Sodium / urine
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Spironolactone / analogs & derivatives*
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Spironolactone / chemical synthesis
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Spironolactone / metabolism
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Spironolactone / pharmacology
Substances
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Mineralocorticoid Receptor Antagonists
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Receptors, Progesterone
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6,6-ethylene-15,16-methylene-3-oxo-17-pregn-4-ene-2,17-carbolactone
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Spironolactone
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Aldosterone
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Sodium
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Potassium