Abstract
Diverse polyfunctionalized quinolines, easily prepared using Lewis acid-catalyzed imino Diels-Alder reactions between corresponding aldimines, were tested for antifungal properties against standardized as well as clinical isolates of clinically important fungi. Among them, 4-pyridyl derivatives displayed the best activities mainly against dermatophytes. The activity appears not to be related neither to the lipophilicity nor to the basicity of compounds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acids / chemistry
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Arthrodermataceae / drug effects
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Arthrodermataceae / growth & development
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Candida / drug effects*
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Candida / growth & development
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Catalysis
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Cryptococcus / drug effects*
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Cryptococcus / growth & development
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Dose-Response Relationship, Drug
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Imines / chemistry
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Microbial Sensitivity Tests
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Molecular Structure
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Quinolines / chemical synthesis*
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Quinolines / chemistry
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Quinolines / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Acids
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Antifungal Agents
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Imines
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Quinolines