The discovery of pyrano[3,4-b]indole-based allosteric inhibitors of HCV NS5B polymerase with in vivo activity

ChemMedChem. 2008 Oct;3(10):1508-15. doi: 10.1002/cmdc.200800168.
No abstract available

MeSH terms

  • Allosteric Regulation
  • Animals
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Hepacivirus / drug effects*
  • Hepacivirus / genetics
  • Hepacivirus / metabolism
  • Indoles / chemical synthesis
  • Indoles / chemistry
  • Indoles / pharmacology
  • Inhibitory Concentration 50
  • Mice
  • Mice, SCID
  • Mice, Transgenic
  • Pyrans / chemical synthesis*
  • Pyrans / chemistry
  • Pyrans / pharmacology*
  • RNA, Viral / blood
  • RNA, Viral / isolation & purification
  • RNA-Dependent RNA Polymerase / antagonists & inhibitors*
  • RNA-Dependent RNA Polymerase / metabolism
  • Viral Nonstructural Proteins / antagonists & inhibitors*
  • Viral Nonstructural Proteins / metabolism

Substances

  • Antiviral Agents
  • Indoles
  • Pyrans
  • RNA, Viral
  • Viral Nonstructural Proteins
  • NS-5 protein, hepatitis C virus
  • RNA-Dependent RNA Polymerase