Abstract
A nucleolar localizing rev gene mutant M10 of human immunodeficiency virus type 1 (HIV-1) lost a Rev function completely, instead, gained a Rex activity of human T cell leukemia virus type 1 (HTLV-1). The obtained compatibility between Rev M10 and Rex with their own nucleolar targeting signal (NOS) suggests a common molecular mechanism of their post-transcriptional regulation, despite no sequence similarities of both proteins and their responsive RNA elements, respectively.
MeSH terms
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Amino Acid Sequence
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Animals
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Cell Line
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Cell Nucleolus / physiology
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Cell Nucleolus / ultrastructure
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Chloramphenicol O-Acetyltransferase / genetics
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Chloramphenicol O-Acetyltransferase / metabolism
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Cloning, Molecular
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Gene Conversion*
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Gene Products, rev / metabolism
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Gene Products, rex / metabolism
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Genes, pX*
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Genes, rev*
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HIV-1 / genetics*
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Human T-lymphotropic virus 1 / genetics*
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Molecular Sequence Data
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Mutation*
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Plasmids
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Transfection
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rev Gene Products, Human Immunodeficiency Virus
Substances
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Gene Products, rev
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Gene Products, rex
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rev Gene Products, Human Immunodeficiency Virus
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Chloramphenicol O-Acetyltransferase