Abstract
Screening of 368 consecutive nonreplicate clinical isolates of Enterobacteriaceae resistant to nalidixic acid and at least one extended-spectrum beta-lactam revealed the presence of qnrA, qnrB, and qnrS determinants, and identified novel qnrB variants, in Citrobacter freundii isolates. This study also revealed, for the first time, the linkage of qnrB, armA, and extended-spectrum and/or AmpC-type beta-lactamase genes on large conjugative plasmids.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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DNA Primers / genetics
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DNA, Bacterial / genetics
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Drug Resistance, Bacterial / genetics*
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Enterobacteriaceae / drug effects*
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Enterobacteriaceae / genetics*
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Enterobacteriaceae / isolation & purification
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Enterobacteriaceae Infections / drug therapy
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Enterobacteriaceae Infections / microbiology
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Genes, Bacterial
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Hospitals, University
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Humans
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Korea
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Molecular Sequence Data
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Quinolones / pharmacology*
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R Factors / genetics
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Sequence Homology, Amino Acid
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beta-Lactam Resistance / genetics
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beta-Lactamases / genetics
Substances
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DNA Primers
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DNA, Bacterial
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Quinolones
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beta-Lactamases
Associated data
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GENBANK/EU273755
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GENBANK/EU273756
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GENBANK/EU273757
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GENBANK/EU302865