Silencing HIV-1 In Vivo

Cell. 2008 Aug 22;134(4):566-8. doi: 10.1016/j.cell.2008.08.004.

Abstract

RNA interference holds great promise for antiviral therapy, but delivering effective quantities of small interfering RNAs (siRNAs) into the right target cells in vivo represents a major challenge. Kumar et al. (2008) now report a technique to target siRNAs specifically to T cells to suppress viral infection in a humanized mouse model of HIV/AIDS.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • HIV Infections / genetics*
  • HIV Infections / therapy*
  • HIV-1 / genetics*
  • Humans
  • Leukocytes, Mononuclear / virology
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • RNA Interference*
  • RNA, Small Interfering / metabolism*

Substances

  • RNA, Small Interfering