A clinicopathologic study of mantle cell lymphoma in a single center study in India

Indian J Pathol Microbiol. 2008 Jul-Sep;51(3):315-22. doi: 10.4103/0377-4929.42503.

Abstract

We present clinical features, histopathology and results of treatment in cases of mantle cell lymphoma (MCL) at our hospital. We had 93 cases (2.1%) of MCL out of total 4301 cases of non-Hodgkin's lymphoma (NHL) in a 4-year period. It included 68 cases (1.7%) of MCL from 3987 cases of NHL diagnosed on histopathology. Remaining 25 cases (7.9%) diagnosed solely on peripheral blood examination were excluded. Thirty-six (85%) patients had advanced-stage disease. Sixty-three were nodal and five were extranodal (all gastrointestinal tract). Common patterns were diffuse (64%), nodular (25%) and mantle zone type (11%). Sixty-two cases had lymphocytic while six had blastic morphology (all nodal). Tumor cells expressed CD20 (100%), CD43 (94%), CD5 (89%) and cyclin D1 (85%). Bone marrow was involved in 25 (59%) cases. Thirty-two patients could be treated. Median recurrence-free survival was 22.23 months. Diffuse pattern of nodal involvement had a lower overall survival.

MeSH terms

  • Adult
  • Aged
  • Antigens, CD20 / biosynthesis
  • Antineoplastic Agents / therapeutic use
  • Bone Marrow / pathology
  • CD5 Antigens / biosynthesis
  • Cyclin D1 / biosynthesis
  • Female
  • Gastrointestinal Tract / pathology
  • Hospitals
  • Humans
  • India
  • Leukosialin / biosynthesis
  • Lymphoma, Mantle-Cell / drug therapy
  • Lymphoma, Mantle-Cell / pathology*
  • Lymphoma, Mantle-Cell / physiopathology*
  • Male
  • Middle Aged
  • Survival Analysis

Substances

  • Antigens, CD20
  • Antineoplastic Agents
  • CCND1 protein, human
  • CD5 Antigens
  • Leukosialin
  • SPN protein, human
  • Cyclin D1