Although science and engineering (S&E) publications and doctoral degree awards in Latin America had experienced an impressive growth in the past decades, a qualitative evaluation of this increased output must be performed. Previous studies have indicated that growth in visibility of Latin American science - determined by ratio of citations per paper - has not kept pace with the increase in number of publications. In the present editorial, we analyzed - by means of a 12-item questionnaire - the individual perceptions of forty senior researchers involved in CBP-Latin America (29 Brazilians and 11 non-Brazilians) plus a special group composed by six extraordinary Latin American scientists (the "masters"). The questionnaire - using 6-point Likert-like scale for quantification of perception - focused on issues surrounding doctoral educational system as well as the governmental educational policies and publication pressure from funding agencies. In general, the most striking result was the perception (by 82% of respondents) of lack of job opportunities for people holding a PhD diploma in the field of comparative biochemistry and physiology. Other major trends include (i) lack of satisfaction with governmental policies for science and post-graduate education due to policies promoting mass production for papers and PhD diplomas (65-77% of respondents felt that way) (ii) that current PhD students are doing an adequate job, but have not improved in quality as compared to those from 10 years ago (the same was observed for PhD thesis in terms of present versus past), and (iii) that research infrastructure and the curricula of post-graduate courses do not constitute a problem, but (iv) recent-PhDs are not as fit as they should be in paper-writing skills, especially as perceived by Brazilian respondents. The general perceptions were very similar among Brazilians, non-Brazilians and "masters". The use of a larger study-population, with scientists of more diverse fields is the next logical step to best evaluate the level of satisfaction about science and post-graduate policies in the continent. Finally, this fifth and last special issue of CBP-Latin America celebrates the contribution of 20 new manuscripts, which adds up to 118 published studies highlighting the depth, breadth and enthusiasm of Latin American comparative biochemistry and physiology - enjoy.