Abstract
Most Actinobacteria produce mycothiol as the major thiol. In addition to mycothiol Rhodococcus AD45 generates a substantial level of glutathione possibly using genes acquired in a lateral transfer. Instead of mycothiol, Rubrobacter radiotolerans and Rubrobacter xylanophilus produce glutathione, whose synthesis appears to involve enzymes substantially different from those in other organisms.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinobacteria / enzymology
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Actinobacteria / genetics
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Actinobacteria / metabolism*
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Amino Acid Sequence
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Cysteine / metabolism
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Glutathione / metabolism*
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Glycopeptides / metabolism
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Inositol / metabolism
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Molecular Sequence Data
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Sequence Alignment
Substances
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Bacterial Proteins
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Glycopeptides
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mycothiol
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Inositol
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Glutathione
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Cysteine