Abstract
Reassortants possessing the hemagglutinin (HA) gene from A/Equine/London/1416/73 (H7N7) [Eq/Lond] and five or more genes from A/Chicken/Pennsylvania/1370/83 (H5N2) [Ck/Penn] were lethal in chickens. This result demonstrates that horses can maintain influenza viruses whose HAs are capable of promoting virulence. Thus, reassortment of equine and avian influenza virus genes could generate viruses that might be lethal in domestic poultry.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Cell Line
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Chick Embryo
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Chickens
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Genotype
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Hemagglutinin Glycoproteins, Influenza Virus
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Hemagglutinins, Viral / genetics
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Hemagglutinins, Viral / physiology*
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Horses
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Influenza A Virus, H7N7 Subtype*
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Influenza A virus / genetics*
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Influenza A virus / immunology
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Influenza A virus / pathogenicity
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Molecular Sequence Data
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Viral Plaque Assay
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Virulence
Substances
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Hemagglutinin Glycoproteins, Influenza Virus
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Hemagglutinins, Viral
Associated data
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GENBANK/M55473
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GENBANK/M55474
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GENBANK/M55475
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GENBANK/M55476
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GENBANK/M55477
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GENBANK/M55478
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GENBANK/M58657
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GENBANK/M64316
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GENBANK/S48634
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GENBANK/S48744