A quick look at slow saccades after cardiac surgery: where is the lesion?

Prog Brain Res. 2008:171:587-90. doi: 10.1016/S0079-6123(08)00685-7.

Abstract

Saccadic palsy is a reported complication of cardiac surgery. One case that came to autopsy showed midline pontine gliosis; however, in most cases, no lesions are evident on neuroimaging. Since the saccadic palsy may range from single large slow saccades to a "staircase" of very small saccades that are normal in speed, it seems plausible that more than one mechanism is possible. Here we postulate that, in those patients who make a staircase of small saccades, loss of cerebellar Purkinje cells could cause fastigial nucleus neurons to fire prematurely, thereby decelerating saccades via inhibitory burst neurons.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Stem / pathology
  • Brain Stem / physiology
  • Cardiac Surgical Procedures / adverse effects*
  • Humans
  • Neural Pathways / physiology
  • Neurons / physiology
  • Ocular Motility Disorders* / etiology
  • Ocular Motility Disorders* / pathology
  • Purkinje Cells / physiology
  • Saccades / physiology*