Abstract
Marine antitumor drugs have been the research focus in the world. Recently, advancement has been made in the investigation of six types of compounds including bryostatin-1, ecteinascidin-743, dolastatin, didemnin B, psammaplin and halichondrin B. In this review, we summarized the recent research progress of the above mentioned marine antitumor drugs and their derivatives. Also, the development tendency of marine antitumor drugs was discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / therapeutic use
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Apoptosis / drug effects
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Biological Products* / isolation & purification
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Biological Products* / pharmacology
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Biological Products* / therapeutic use
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Bryostatins / isolation & purification
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Bryostatins / pharmacology
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Bryostatins / therapeutic use
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Cell Line, Tumor / drug effects
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Depsipeptides / isolation & purification
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Depsipeptides / pharmacology
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Depsipeptides / therapeutic use
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Dioxoles / isolation & purification
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Dioxoles / pharmacology
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Dioxoles / therapeutic use
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Disulfides / isolation & purification
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Disulfides / pharmacology
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Ethers, Cyclic / isolation & purification
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Ethers, Cyclic / pharmacology
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Humans
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Macrolides
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Marine Biology*
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Neoplasms* / drug therapy
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Neoplasms* / pathology
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Tetrahydroisoquinolines / isolation & purification
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Tetrahydroisoquinolines / pharmacology
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Tetrahydroisoquinolines / therapeutic use
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Trabectedin
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Tyrosine / analogs & derivatives
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Tyrosine / isolation & purification
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Tyrosine / pharmacology
Substances
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Antineoplastic Agents
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Biological Products
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Bryostatins
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Depsipeptides
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Dioxoles
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Disulfides
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Ethers, Cyclic
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Macrolides
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Tetrahydroisoquinolines
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psammaplin A
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halichondrin B
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bryostatin 1
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Tyrosine
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didemnins
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dolastatin 10
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Trabectedin