Abstract
Orbital involvement in chronic lymphocytic leukemia (CLL) is highly unusual and most commonly involves hemorrhage or soft tissue infiltration in advanced disease. We report a case of rapid onset bilateral orbital muscle infiltration as the presenting feature of early stage CLL. In addition, we demonstrate clinico-pathological correlation with an identical chronic B-cell lymphocytic infiltrate in both orbit and bone marrow, with good response of the orbital disease to local radiotherapy.
MeSH terms
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Aged
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Antigens, CD / analysis
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Combined Modality Therapy
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Functional Laterality
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Glucocorticoids / therapeutic use
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Humans
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Immunophenotyping
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Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
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Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
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Leukemia, Lymphocytic, Chronic, B-Cell / radiotherapy
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Leukemic Infiltration / drug therapy
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Leukemic Infiltration / pathology*
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Leukemic Infiltration / radiotherapy
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Magnetic Resonance Imaging
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Male
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Methylprednisolone / therapeutic use
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Oculomotor Muscles / drug effects
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Oculomotor Muscles / pathology*
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Orbital Neoplasms / drug therapy
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Orbital Neoplasms / pathology*
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Orbital Neoplasms / radiotherapy
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Radiotherapy
Substances
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Antigens, CD
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Glucocorticoids
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Methylprednisolone