Infliximab therapy for 2 patients with Vogt-Koyanagi-Harada syndrome

Ocul Immunol Inflamm. 2008 Jul-Aug;16(4):167-71. doi: 10.1080/09273940802204527.

Abstract

Purpose: To report the authors' experience using infliximab to treat 2 patients with Vogt-Koyanagi-Harada disease (VKH).

Design: Interventional case series.

Methods: Medical records of the 2 patients were reviewed.

Results: After starting infliximab intravenous infusions, 5 mg/kg, both patients experienced rapid improvement in their VKH disease, and were able to taper and discontinue prednisone without disease recurrence for the several-month follow-up period.

Conclusions: Infliximab may be effective treatment for VKH, and spares patients the side effects of corticosteroids and conventional immunosuppressive drugs.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / therapeutic use*
  • Antibodies, Monoclonal / therapeutic use*
  • Female
  • Fluorescein Angiography
  • Humans
  • Infliximab
  • Male
  • Tumor Necrosis Factor-alpha / immunology
  • Uveomeningoencephalitic Syndrome / drug therapy*
  • Visual Acuity

Substances

  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal
  • Tumor Necrosis Factor-alpha
  • Infliximab