Available are the results of treatment of 104 females suffering from spontaneous cyclic abdominal pain. Clinical and paraclinical evaluation shows that sensibilization to certain estrogen fraction in the presence of estrogen-progesterone++ imbalance plays the leading role in pathogenesis of cyclic (phase I, II and in the middle of the cycle) abdominal pain. Desensitization by intracutaneous introduction of relevant estrogen fraction combined with progesterone++ provides recovery of vegetative and estrogen-progesterone++ balance, relief of pain and emotional stress. A complete response was achieved in 64.4%, partial in 25%, no response in 10.6% of the patients. Follow-up lasted for 1 to 17 years. Additional rehabilitation measures are suggested. The diagnosis and treatment were performedon the outpatient basis.