Abstract
The env open reading frames of African lion (Panthera leo) lentivirus (feline immunodeficiency virus [FIV(Ple)]) subtypes B and E from geographically distinct regions of Africa suggest two distinct ancestries, with FIV(Ple)-E sharing a common ancestor with the domestic cat (Felis catus) lentivirus (FIV(Fca)). Here we demonstrate that FIV(Ple)-E and FIV(Fca) share the use of CD134 (OX40) and CXCR4 as a primary receptor and coreceptor, respectively, and that both lion CD134 and CXCR4 are functional receptors for FIV(Ple)-E. The shared usage of CD134 and CXCR4 by FIV(Fca) and FIV(Ple)-E may have implications for in vivo cell tropism and the pathogenicity of the E subtype among free-ranging lion populations.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cats / virology*
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Cell Line
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Genes, Reporter
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Giant Cells / cytology
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Giant Cells / virology
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Immunodeficiency Virus, Feline / genetics
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Immunodeficiency Virus, Feline / isolation & purification
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Immunodeficiency Virus, Feline / physiology*
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Lions / virology*
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Luciferases / genetics
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Luciferases / metabolism
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Molecular Sequence Data
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RNA, Viral / genetics
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Receptors, CXCR4 / metabolism*
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Receptors, OX40 / metabolism*
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Receptors, Virus*
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Sequence Analysis, DNA
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Virus Internalization*
Substances
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RNA, Viral
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Receptors, CXCR4
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Receptors, OX40
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Receptors, Virus
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Luciferases
Associated data
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GENBANK/EU915482
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GENBANK/EU915483
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GENBANK/EU915484