Furan oligomers and beta-carbolines from terrestrial streptomycetes

Serge Fotso; Rajendra P Maskey; Dirk Schröder; Anna S Ferrer; Iris Grün-Wollny; Hartmut Laatsch

doi:10.1021/np800248s

Furan oligomers and beta-carbolines from terrestrial streptomycetes

J Nat Prod. 2008 Sep;71(9):1630-3. doi: 10.1021/np800248s. Epub 2008 Aug 21.

Authors

Serge Fotso¹, Rajendra P Maskey, Dirk Schröder, Anna S Ferrer, Iris Grün-Wollny, Hartmut Laatsch

Affiliation

¹ Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.

PMID: 18715034
DOI: 10.1021/np800248s

Abstract

2,5-Bis(hydroxymethyl)furan monoacetate (3) and 2,5-bis(hydroxymethyl)furan diacetate (4) were obtained as new natural products from an ethyl acetate extract of the terrestrial Streptomyces sp. isolate GW11/1695. Another Streptomyces isolate, GW21/1313, delivered a dimer (6) and a trimer (7) of (hydroxymethyl)furfural. The latter strain also produced 4-hydroxy-2-(5-(hydroxymethyl)furan-2-ylmethylene)-5-methylfuran-3-one (5), perlolyrin (8), and two new beta-carboline derivatives, 9 and 10. 2,5-Bis(hydroxymethyl)furan diacetate (4) exhibited weak cytotoxic activity against brine shrimp larvae.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Artemia / drug effects
Furans / chemistry
Furans / isolation & purification*
Furans / pharmacology
Larva / drug effects
Molecular Structure
Streptomyces / chemistry*

Substances

Furans