Abstract
We report the observation of bilayer fragments, some of which close to form vesicles, over a large range of pH at room temperature from mixtures of single-chain biocompatible commercially available nontoxic alkyl carboxylic surfactants after neutralization with HCl. The pH at which the morphological transitions occur is varied only by changing the ratio between two surfactants: the alkyloligoethyleneoxide carboxylate and sodium laurate. The effect of aging of the mixed surfactant systems in the pH region desired for dermatologic application (4.5 < pH < 7) is also studied. Finally, we show results of cytotoxicity studies on the surfactant mixtures.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biocompatible Materials / chemistry
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Carboxylic Acids / chemistry*
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Cryoelectron Microscopy
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HeLa Cells
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Humans
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Hydrochloric Acid / chemistry
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Hydrogen-Ion Concentration*
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Lauric Acids / chemistry
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Light
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Lipid Bilayers / chemistry*
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Microscopy, Electron, Transmission
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Phase Transition
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Surface-Active Agents
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Tetrazolium Salts / chemistry
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Tetrazolium Salts / pharmacology
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Thiazoles / chemistry
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Thiazoles / pharmacology
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Time Factors
Substances
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Biocompatible Materials
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Carboxylic Acids
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Lauric Acids
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Lipid Bilayers
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Surface-Active Agents
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Tetrazolium Salts
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Thiazoles
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lauric acid
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thiazolyl blue
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Hydrochloric Acid