Abstract
Continuing our research on the development of nucleopeptides as ODN analogs for biomedical and bioengineering applications, here we report the synthesis and the chemical-physical characterization of a homoadenine hexamer based on a l-diaminobutyric acid (l-DABA) backbone (dabPNA), and its binding studies with a complementary aegPNA. We demonstrated by CD and UV experiments that the l-dabPNA binds the aegPNA forming a complex with good thermal stability, that we identified as a left-handed triplex.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine Nucleotides / chemical synthesis
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Adenine Nucleotides / chemistry
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Adenine Nucleotides / metabolism
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Aminobutyrates / chemistry*
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Aminobutyrates / metabolism*
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Circular Dichroism
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DNA / chemistry
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DNA / metabolism
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Drug Design
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Glycine / analogs & derivatives*
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Glycine / chemistry
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Glycine / metabolism
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Magnetic Resonance Spectroscopy
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Peptide Nucleic Acids / chemical synthesis
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Peptide Nucleic Acids / chemistry*
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Peptide Nucleic Acids / isolation & purification
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Peptide Nucleic Acids / metabolism*
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Spectrometry, Mass, Electrospray Ionization
Substances
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Adenine Nucleotides
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Aminobutyrates
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Peptide Nucleic Acids
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aminoethylglycyl PNA
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triplex DNA
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DNA
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Glycine