Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors

Pedro Carlos Lara; Marta Lloret; Bernardino Clavo; Rosa Maria Apolinario; Elisa Bordón; Agustin Rey; Orlando Falcón; Ana Ruiz Alonso; Claus Belka

doi:10.1016/j.radonc.2008.07.018

Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors

Radiother Oncol. 2008 Nov;89(2):222-6. doi: 10.1016/j.radonc.2008.07.018. Epub 2008 Aug 14.

Authors

Pedro Carlos Lara¹, Marta Lloret, Bernardino Clavo, Rosa Maria Apolinario, Elisa Bordón, Agustin Rey, Orlando Falcón, Ana Ruiz Alonso, Claus Belka

Affiliation

¹ Radiation Oncology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain. plara@dcc.ulpgc.es

PMID: 18706726
DOI: 10.1016/j.radonc.2008.07.018

Abstract

Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Antigens, Nuclear / genetics*
DNA-Binding Proteins / genetics*
Down-Regulation
Female
Humans
Hypoxia / genetics*
Immunoenzyme Techniques
Ku Autoantigen
Middle Aged
Prospective Studies
Uterine Cervical Neoplasms / genetics*
Uterine Cervical Neoplasms / radiotherapy

Substances

Antigens, Nuclear
DNA-Binding Proteins
Xrcc6 protein, human
Ku Autoantigen