Histologic and clinical evaluation for maxillary sinus augmentation using macroporous biphasic calcium phosphate in human

Clin Oral Implants Res. 2008 Aug;19(8):767-71. doi: 10.1111/j.1600-0501.2008.01520.x.

Abstract

Objectives: This study evaluated both the clinical and histological aspects of bone formation in maxillary sinus augmentation using MBCP as the bone-grafting material.

Material and methods: MBCP was used as a primary bone substitute for maxillary sinus augmentation. Fifty-two patients were selected after a medical and dental examination, and were divided into the following three groups: those augmented with MBCP only; MBCP combined with irradiated cancellous bone; and MBCP combined with intraoral autogenous bone. After a healing period (average 6.78 months after surgery), bone cores were harvested for a histological evaluation and the implant fixtures were installed. These bone cores were evaluated via light microscope and implants were followed up for at least six months after loading.

Results: Four to ten months after surgery, new vital bone surrounding the MBCP particles was observed in 18 bone biopsies. Two out of the 130 implants installed were explanted due to a failure of osseointegration before the prosthetic procedure. All the remaining implants were functioning for 6 to 27 months (average 12.96 months). The cumulative survival rate of the implants was 98.46%.

Conclusion: These results show that MBCP can be used as a grafting material for sinus floor augmentation, whether combined with other bone graft materials or not, and lead to a predictable prognosis for dental implants in the posterior maxillary area where there is insufficient vertical height for fixture installation.

Publication types

  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alveolar Bone Loss / pathology
  • Alveolar Bone Loss / surgery*
  • Alveolar Ridge Augmentation / methods*
  • Biocompatible Materials / therapeutic use
  • Bone Matrix / transplantation
  • Bone Substitutes / therapeutic use*
  • Bone Transplantation / methods*
  • Calcium Phosphates / therapeutic use
  • Dental Implantation, Endosseous / methods
  • Female
  • Humans
  • Male
  • Maxilla / pathology
  • Maxilla / surgery*
  • Maxillary Sinus / pathology
  • Maxillary Sinus / surgery
  • Middle Aged
  • Oral Surgical Procedures, Preprosthetic / methods
  • Osseointegration / drug effects
  • Osseointegration / physiology
  • Treatment Outcome

Substances

  • Biocompatible Materials
  • Bone Substitutes
  • Calcium Phosphates