Interrelations of mitochondrial fragmentation and cell death under ischemia/reoxygenation and UV-irradiation: protective effects of SkQ1, lithium ions and insulin

FEBS Lett. 2008 Sep 3;582(20):3117-24. doi: 10.1016/j.febslet.2008.08.002. Epub 2008 Aug 12.

Abstract

Mitochondria-targeted antioxidant 10-(6-plastoquinonyl)decyltriphenyl-phosphonium (SkQ1) as well as insulin and the inhibitor of glycogen-synthase kinase, Li(+) are shown to (i) protect renal tubular cells from an apoptotic death and (ii) diminish mitochondrial fission (the thread-grain transition) induced by ischemia/reoxygenation. However, SkQ1 and LiCl protected the mitochondrial reticulum of skin fibroblasts from ultraviolet-induced fission but were ineffective in preventing a further cell death. This means that mitochondrial fission is not essential for apoptotic cascade progression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Apoptosis* / drug effects
  • Cytoprotection*
  • Enzyme Inhibitors / pharmacology
  • Epithelium / drug effects
  • Epithelium / radiation effects
  • Epithelium / ultrastructure
  • Fibroblasts / drug effects
  • Fibroblasts / radiation effects
  • Fibroblasts / ultrastructure
  • Glycogen Synthase Kinases / antagonists & inhibitors
  • Insulin / pharmacology*
  • Kidney Tubules / drug effects
  • Kidney Tubules / radiation effects
  • Kidney Tubules / ultrastructure
  • Lithium Chloride / pharmacology*
  • Mitochondria / drug effects
  • Mitochondria / radiation effects
  • Mitochondria / ultrastructure*
  • Oxygen / metabolism
  • Plastoquinone / analogs & derivatives*
  • Plastoquinone / pharmacology
  • Rats
  • Skin / drug effects
  • Skin / radiation effects
  • Skin / ultrastructure
  • Ultraviolet Rays

Substances

  • 10-(6'-plastoquinonyl)decyltriphenylphosphonium
  • Antioxidants
  • Enzyme Inhibitors
  • Insulin
  • Glycogen Synthase Kinases
  • Lithium Chloride
  • Plastoquinone
  • Oxygen