Abstract
A deep cavitand with an inwardly directed carboxylic acid function reacts with small aliphatic isonitriles to form N-acyl formamides inside the cavity. The unique isolation and stabilization of covalently bound guests within the structured environment of the cavitand allows for observation of the labile O-acyl isoimide intermediate using conventional spectroscopic methods.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Carboxylic Acids / chemistry*
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Ethers, Cyclic / chemistry*
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Formamides / chemical synthesis
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Formamides / chemistry
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Imides / chemistry*
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Magnetic Resonance Spectroscopy / methods
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Nitriles / chemistry*
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Resorcinols / chemistry*
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Spectrophotometry, Infrared
Substances
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Carboxylic Acids
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Ethers, Cyclic
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Formamides
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Imides
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Nitriles
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Resorcinols
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cavitand