Four new sesquiterpene lactones, 11-epi-8-desoxyartelin (1), sonchifoliasolide A (2), sonchifoliasolide B (3), and sonchifoliasolide C (4) were isolated from the roots of Ixeris sonchifolia (Bge.) Hance. The structures of compounds 1-4 were established on the basis of their spectroscopic data.