Abstract
In situ generated aryl, heteroaryl, alkyl, or benzylic polyfunctional zinc reagents obtained by the addition of zinc and LiCl to the corresponding organic iodides undergo smooth Pd(0)-catalyzed cross-coupling reactions with aryl bromides, chlorides, and triflates in the presence of PEPPSI as a catalyst. This procedure avoids the manipulation of water and air-sensitive organozinc reagents and produces cross-coupling products in high yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Hydrocarbons, Brominated / chemistry*
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Hydrocarbons, Chlorinated / chemistry*
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Lithium Chloride / chemistry
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Mesylates / chemistry*
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Molecular Structure
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / chemistry
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Stereoisomerism
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Zinc / chemistry*
Substances
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Hydrocarbons, Brominated
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Hydrocarbons, Chlorinated
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Mesylates
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Organometallic Compounds
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Lithium Chloride
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Zinc
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trifluoromethanesulfonic acid