A novel steroid from Elephantopus scaber L. an ethnomedicinal plant with antidiabetic activity

P Daisy; R Jasmine; S Ignacimuthu; E Murugan

doi:10.1016/j.phymed.2008.06.001

A novel steroid from Elephantopus scaber L. an ethnomedicinal plant with antidiabetic activity

Phytomedicine. 2009 Mar;16(2-3):252-7. doi: 10.1016/j.phymed.2008.06.001. Epub 2008 Aug 6.

Authors

P Daisy¹, R Jasmine, S Ignacimuthu, E Murugan

Affiliation

¹ Department of Biotechnology, Holy Cross College, Tiruchirappalli 620002, India.

PMID: 18693100
DOI: 10.1016/j.phymed.2008.06.001

Abstract

Acetone extract of Elephantopus scaber, an ethnomedicnal plant, reduced the blood glucose levels in streptozotocin-induced diabetic rats significantly. Acute toxicity studies revealed the non-toxic nature of the crude extract. Fractionation of the acetone extract yielded a new steroid, 28Nor-22(R)Witha 2,6,23-trienolide. Biological testing of the compound demonstrated a significant antidiabetic activity by reducing the elevated blood glucose levels and restoring the insulin levels in streptozotocin-induced diabetic rats. This compound can be a useful candidate to treat diabetes.

MeSH terms

Animals
Asteraceae / chemistry*
Blood Glucose / metabolism*
Diabetes Mellitus, Experimental / drug therapy*
Ergosterol / adverse effects
Ergosterol / analogs & derivatives*
Ergosterol / chemistry
Ergosterol / isolation & purification
Ergosterol / therapeutic use
Glyburide / therapeutic use
Hypoglycemic Agents / adverse effects
Hypoglycemic Agents / chemistry
Hypoglycemic Agents / isolation & purification
Hypoglycemic Agents / therapeutic use*
Insulin / blood*
Insulin / therapeutic use
Male
Phytotherapy*
Plant Extracts / adverse effects
Plant Extracts / chemistry
Plant Extracts / therapeutic use
Rats

Substances

28-nor-22-witha-2,6,23-trienolide
Blood Glucose
Hypoglycemic Agents
Insulin
Plant Extracts
Glyburide
Ergosterol