ATM breaks into heterochromatin

Mol Cell. 2008 Aug 8;31(3):303-4. doi: 10.1016/j.molcel.2008.07.004.

Abstract

Heterochromatin is refractory to DNA transactions, including repair. In a recent issue of Molecular Cell, Goodarzi et al. (2008) reveal how the central transducing kinase of the DNA damage response relieves this natural barrier by increasing heterochromatic DNA accessibility.

Publication types

  • Comment

MeSH terms

  • Animals
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins / metabolism*
  • Chromatin Assembly and Disassembly
  • DNA Damage
  • DNA Repair
  • DNA-Binding Proteins / metabolism*
  • Heterochromatin / metabolism*
  • Humans
  • Phosphorylation
  • Protein Serine-Threonine Kinases / metabolism*
  • Tumor Suppressor Proteins / metabolism*

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Heterochromatin
  • Tumor Suppressor Proteins
  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • Protein Serine-Threonine Kinases