Immobilization of black bears (Ursus americanus) with a combination of butorphanol, azaperone, and medetomidine

J Wildl Dis. 2008 Jul;44(3):748-52. doi: 10.7589/0090-3558-44.3.748.

Abstract

Sixteen captive and five free-ranging black bears (Ursus americanus) were immobilized with a combination of butorphanol, azaperone, and medetomidine (BAM). The BAM drug combination was premixed using 0.5 ml butorphanol (30 mg/ml), 0.25 ml azaperone (50 mg/ml), and 0.25 ml medetomidine (20 mg/ml) per milliliter to yield a final mix of (15 mg butorphanol+12.5 mg azaperone+5 mg medetomidine)/ml. This combination, dosed at 0.4 ml BAM/approximately 23 kg estimated body weight, provided a mean induction time of 10 min (95% confidence interval [CI]=2 min), consistent anesthesia without apparent adverse effects, and smooth recovery (mean=15 min, 95% CI=4 min) after antagonism with atipamezole (5 mg/mg medetomidine) alone or in combination with naltrexone (5 mg/mg butorphanol). Based on our initial observations, BAM appears to be a reversible and accessible drug combination for immobilizing black bears that merits further evaluation for field use.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anesthetics, Combined / administration & dosage*
  • Animals
  • Animals, Wild
  • Azaperone / administration & dosage
  • Blood Pressure / drug effects
  • Body Temperature / drug effects
  • Butorphanol / administration & dosage
  • Dose-Response Relationship, Drug
  • Female
  • Heart Rate / drug effects
  • Hypnotics and Sedatives / administration & dosage*
  • Immobilization / methods
  • Immobilization / veterinary*
  • Male
  • Medetomidine / administration & dosage
  • Narcotics / administration & dosage
  • Respiration / drug effects
  • Ursidae / physiology*

Substances

  • Anesthetics, Combined
  • Hypnotics and Sedatives
  • Narcotics
  • Azaperone
  • Medetomidine
  • Butorphanol