[RuII(NO+)]3+-core complexes with 4-methyl-pyrimidine and ethyl-isonicotinate: synthesis, X-ray structure, spectroscopy, and computational and NO-release studies upon UVA irradiation

J Inorg Biochem. 2008 Oct;102(10):1874-84. doi: 10.1016/j.jinorgbio.2008.06.011. Epub 2008 Jun 22.

Abstract

The reaction of RuCl(3)(NO).H(2)O with 4-methylpyrimidine (MePYM) and ethylisonicotinate (EINT), in absolute ethanol at 40-55 degrees C afforded crystalline trans-[RuCl(3)(NO)L(2)] complexes. Structural studies via X-ray diffraction, and spectroscopic methods (NMR, IR, UV-visible (UV-Vis)) revealed that the molecular structures have the two Ls in trans positions (axial) and the chloride anions and the NO(+) cation as equatorial ligands; pyrimidine...pyrimidine pairing pattern via two weak C-H...N interactions occur. The molecular structures for the EINT derivative was inferred from spectroscopy and computations. Under irradiation at 366 nm several solutions of the title compounds deliver NO via first order processes. Visible light (420-700 nm) does not produce significant NO release from CH(2)Cl(2) and CH(3)CN solutions within 24h.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Isonicotinic Acids / chemistry*
  • Ligands
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Organometallic Compounds / chemical synthesis
  • Organometallic Compounds / chemistry*
  • Pyrimidines / chemistry*
  • Ruthenium Compounds / chemistry*
  • Spectrum Analysis
  • Ultraviolet Rays
  • X-Ray Diffraction

Substances

  • Isonicotinic Acids
  • Ligands
  • Organometallic Compounds
  • Pyrimidines
  • Ruthenium Compounds
  • ethyl isonicotinate
  • pyrimidine