Recent advances in the genetics of diabetes

Ewan R Pearson

doi:10.1016/j.pcd.2007.12.005

Recent advances in the genetics of diabetes

Prim Care Diabetes. 2008 Jun;2(2):67-72. doi: 10.1016/j.pcd.2007.12.005. Epub 2008 Feb 12.

Author

Ewan R Pearson¹

Affiliation

¹ Division of Medicine & Therapeutics, Ninewells Hospital & Medical School, Dundee DD19SY, United Kingdom. e.pearson@chs.dundee.ac.uk

PMID: 18684425
DOI: 10.1016/j.pcd.2007.12.005

Abstract

After many years of effort with only modest result, the last 5 years has seen a tremendous surge in our understanding of the genetics of diabetes. This review will focus on the therapeutic implications of diagnosing monogenic diabetes and the recent advances in type 1 and type 2 diabetes genetics following the development of Genome Wide Association studies.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Blood Glucose
Diabetes Mellitus / drug therapy*
Diabetes Mellitus / genetics*
Genetic Predisposition to Disease / genetics*
Hepatocyte Nuclear Factor 1-alpha / metabolism
Humans
Hypoglycemic Agents / therapeutic use*
Potassium Channels, Inwardly Rectifying / metabolism

Substances

Blood Glucose
HNF1A protein, human
Hepatocyte Nuclear Factor 1-alpha
Hypoglycemic Agents
Kir6.2 channel
Potassium Channels, Inwardly Rectifying