Abstract
Quantitative measurements of the Hunchback transcription factor in Drosophila embryos show that its target genes can respond with a high degree of precision to the exact level of the protein, simulating a continuous, analog readout, while other target genes show a combinatorial effect, resembling a Boolean logic element.
MeSH terms
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Animals
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Body Patterning / genetics
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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DNA-Binding Proteins / physiology
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Drosophila / embryology*
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Drosophila / genetics
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Drosophila / metabolism
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Drosophila Proteins / genetics
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Drosophila Proteins / metabolism*
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Drosophila Proteins / physiology
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Embryo, Nonmammalian / metabolism*
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Embryonic Development / genetics
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Evolution, Molecular
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Gene Expression Regulation, Developmental*
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Homeodomain Proteins / genetics
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Homeodomain Proteins / metabolism
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Models, Genetic
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Trans-Activators / genetics
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Trans-Activators / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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Transcription Factors / physiology
Substances
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DNA-Binding Proteins
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Drosophila Proteins
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Homeodomain Proteins
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Trans-Activators
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Transcription Factors
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bcd protein, Drosophila
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hb protein, Drosophila