Moving toward individualized cancer therapies

Clin Cancer Res. 2008 Aug 1;14(15):4682-4. doi: 10.1158/1078-0432.CCR-08-1134.

Abstract

In vivo analysis of the gene expression profiles of cancer cells before and after treatment in patients may define mechanisms of sensitivity and resistance to specific drugs and ultimately allow for the selection of optimal individualized therapy to improve outcome in cancer.

Publication types

  • Review

MeSH terms

  • Apoptosis
  • Drug Resistance, Neoplasm
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Kinetics
  • Medical Oncology / methods
  • Neoplasms / genetics*
  • Neoplasms / therapy*
  • Pharmacogenetics / methods*
  • Sensitivity and Specificity
  • Treatment Outcome