Studies on the anti-phospholipase A2 and anti-inflammatory activities of a synthetic nonapeptide from uteroglobin

Arzneimittelforschung. 1991 Mar;41(3):240-3.

Abstract

The nonapeptide H-Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH (antiflammin), corresponding to a high amino acid similarity region of uteroglobin was prepared by solution and solid phase synthesis. The peptide do not inhibit pancreatic phospholipase A2 in vitro and the carrageenin-induced oedema in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal*
  • Carrageenan
  • Edema / chemically induced
  • Edema / prevention & control
  • Male
  • Molecular Sequence Data
  • Peptide Fragments / chemistry
  • Peptide Fragments / pharmacology*
  • Phospholipases A / antagonists & inhibitors*
  • Phospholipases A2
  • Rats
  • Rats, Inbred Strains
  • Uteroglobin / chemistry
  • Uteroglobin / pharmacology*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Peptide Fragments
  • antiflammin P1
  • Carrageenan
  • Uteroglobin
  • Phospholipases A
  • Phospholipases A2