Abstract
The nonapeptide H-Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH (antiflammin), corresponding to a high amino acid similarity region of uteroglobin was prepared by solution and solid phase synthesis. The peptide do not inhibit pancreatic phospholipase A2 in vitro and the carrageenin-induced oedema in vivo.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Anti-Inflammatory Agents, Non-Steroidal*
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Carrageenan
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Edema / chemically induced
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Edema / prevention & control
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Male
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Molecular Sequence Data
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Peptide Fragments / chemistry
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Peptide Fragments / pharmacology*
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Phospholipases A / antagonists & inhibitors*
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Phospholipases A2
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Rats
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Rats, Inbred Strains
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Uteroglobin / chemistry
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Uteroglobin / pharmacology*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Peptide Fragments
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antiflammin P1
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Carrageenan
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Uteroglobin
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Phospholipases A
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Phospholipases A2