A longitudinal study of comparison of the Kato-Katz technique and indirect hemagglutination assay (IHA) for the detection of schistosomiasis japonica in China, 2001-2006

Acta Trop. 2008 Sep;107(3):251-4. doi: 10.1016/j.actatropica.2008.06.009. Epub 2008 Jul 15.

Abstract

From 2001 to 2006, about one-third of the residents aged 5-65 years were selected as the subjects in a schistosome-endemic village located in Jiangxi Province, China. Every 1 year, all participants were analyzed by the Kato-Katz parasitologic examination and indirect hemagglutination assay (IHA). Statistical analysis of the results showed the k indices ranged from 0.250 to 0.347 between the two methods. Assuming the Kato-Katz results as the gold standard reference, the specificity of the IHA was from 60% to 77%, the positive predictive value of this method was from 19% to 30%, and its sensitivity and negative predictive value were more than 97%. The IHA method is unsuitable for individual screening in endemic community with relatively high prevalence (e.g. with >10% or more prevalence). A search for a better diagnostic test that can be applied in field situations in China is essential and should be given high priority.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Animals
  • Child
  • Child, Preschool
  • China / epidemiology
  • Hemagglutination Tests / methods
  • Humans
  • Longitudinal Studies
  • Middle Aged
  • Parasitology / methods
  • Predictive Value of Tests
  • Schistosoma japonicum / isolation & purification*
  • Schistosomiasis japonica / diagnosis*
  • Schistosomiasis japonica / epidemiology
  • Sensitivity and Specificity