An approach to the mechanical constitutive modelling of arterial tissue based on homogenization and optimization

J Biomech. 2008 Aug 28;41(12):2673-80. doi: 10.1016/j.jbiomech.2008.06.020. Epub 2008 Jul 31.

Abstract

This paper is concerned with characterizing the quasistatic mechanical behaviour of arterial tissue undergoing finite deformation through hyperelastic constitutive functions. Commonly the parameters of constitutive functions are established by a process of optimization based on experimental data. Instead we construct a finite element model of a representative volume element of the material and compute its homogenized response to a range of deformations. These data are then used to provide objective functions for optimizing the parameters of two analytical models from the literature.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Animals
  • Arteries / physiology*
  • Biophysical Phenomena / physiology
  • Blood Pressure / physiology*
  • Computer Simulation
  • Elastic Modulus
  • Humans
  • Models, Cardiovascular*
  • Shear Strength
  • Stress, Mechanical
  • Vascular Resistance / physiology