We report highly versatile nanosensors using polymer single nanowires. On the basis of the optical response of waveguiding polymer single nanowires when exposed to specimens, functionalized polymer nanowires are used for humidity sensing with a response time of 30 ms and for NO 2 and NH 3 detection down to subparts-per-million level. The compact and flexible sensing scheme shown here may be attractive for very fast detection in physical, chemical, and biological applications with high sensitivity and small footprint.