Selective inhibitory effects of hybrid liposomes on the growth of HIV type 1-infected cells in vitro

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4578-80. doi: 10.1016/j.bmcl.2008.07.030. Epub 2008 Jul 15.

Abstract

A good correlation between fifty-percent inhibitory concentration (IC(50)) of hybrid liposomes (HL) composed of dimyristoylphosphatidylcholine and polyoxyethylene(n) dodecyl ether on the growth of MOLT-4/IIIB cells (MOLT-4 cells chronically infected with human immunodeficiency virus (HIV)) and the membrane fluidity of HL was obtained. Furthermore, the huge enhancement of virus production was observed in the latently HIV-infected (J(22)-HL-60) cells after the treatment with HL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Membrane / metabolism
  • Cell Membrane / virology*
  • Cell Survival / drug effects
  • Chemistry, Pharmaceutical / methods
  • Drug Design
  • HIV Infections / drug therapy*
  • HIV-1 / metabolism*
  • HL-60 Cells
  • Humans
  • In Vitro Techniques
  • Inhibitory Concentration 50
  • Liposomes / chemistry
  • Liposomes / therapeutic use*
  • Membrane Fluidity
  • Models, Biological
  • Models, Chemical

Substances

  • Liposomes