Abstract
A novel one-pot tandem synthesis of 2-styryl-4(3 H)-quinazolinones in an acidic ionic liquid is reported. In this procedure isatoic anhydride, a primary aniline or ammonium acetate, and triethylorthoacetate are reacted in the presence of imidazolium trifluoroacetate [Hmim]TFA. Subsequently an aromatic aldehyde is added to the mixture to afford the title compounds in high to excellent yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / chemistry
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Aldehydes / chemistry
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Aniline Compounds / chemistry
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Hydrogen-Ion Concentration
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Imidazoles / chemistry
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Ionic Liquids / chemistry*
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Models, Chemical
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Oxazines / chemistry
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Quinazolinones / chemical synthesis*
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Trifluoroacetic Acid / chemistry
Substances
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Acetates
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Aldehydes
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Aniline Compounds
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Imidazoles
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Ionic Liquids
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Oxazines
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Quinazolinones
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Trifluoroacetic Acid
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isatoic anhydride
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aniline