Carbimazole embryopathy-bilateral choanal atresia and patent vitello-intestinal duct: a case report and review of literature

Birth Defects Res A Clin Mol Teratol. 2008 Sep;82(9):649-51. doi: 10.1002/bdra.20483.

Abstract

Background: In utero exposure to carbimazole for maternal hyperthyroidism has been reported to cause choanal atresia. There are case reports of patent vitello-intestinal duct and Meckel's diverticulum in similar association.

Case: We report another such instance of an infant who was exposed to carbimazole in utero, presenting with bilateral choanal atresia and patent vitello-intestinal duct.

Conclusions: As there seems to be no reports of a possible association between propylthiouracil and congenital malformations, it may be safer to use propylthiouracil instead of carbimazole.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Abnormalities, Drug-Induced / embryology*
  • Antithyroid Agents / adverse effects*
  • Carbimazole / adverse effects*
  • Choanal Atresia / chemically induced*
  • Choanal Atresia / embryology*
  • Choanal Atresia / surgery
  • Female
  • Humans
  • Infant
  • Male
  • Pregnancy
  • Vitelline Duct / abnormalities*
  • Vitelline Duct / embryology

Substances

  • Antithyroid Agents
  • Carbimazole