In vitro withanolide production by Withania somnifera L. cultures

Z Naturforsch C J Biosci. 2008 May-Jun;63(5-6):409-12. doi: 10.1515/znc-2008-5-616.

Abstract

In vitro multiple shoots, root, callus and cell suspension cultures of Withania somnifera exhibited the potentiality to produce pharmacologically active withanolides. Multiple shoots cultures exhibited an increase in withanolide A accumulation compared to shoots of the mother plant. In vitro generated root cultures as well as callus and suspension cultures also produced withanolides albeit at lower levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Ergosterol / analogs & derivatives*
  • Ergosterol / biosynthesis
  • Flowers / metabolism
  • Indoleacetic Acids / metabolism
  • Plant Leaves / cytology
  • Plant Leaves / metabolism
  • Plant Roots / metabolism
  • Plant Shoots / metabolism
  • Withania / metabolism*
  • Withanolides

Substances

  • 3-rhamnopyranosyl(1-4)-glucopyranosyl-12-diacetoxy-20-hydroxywitha-5,24-dienolide
  • Indoleacetic Acids
  • Withanolides
  • indoleacetic acid
  • Ergosterol