Rational design and synthesis of 2,2-bisheterocycle tandem derivatives as non-nucleoside hepatitis B virus inhibitors

ChemMedChem. 2008 Sep;3(9):1316-21. doi: 10.1002/cmdc.200800136.

Authors

Hai-Jun Chen¹, Wen-Long Wang, Gui-Feng Wang, Li-Ping Shi, Min Gu, Yu-Dan Ren, Li-Fei Hou, Pei-Lan He, Feng-Hua Zhu, Xian-Gen Zhong, Wei Tang, Jian-Ping Zuo, Fa-Jun Nan

Affiliation

¹ Chinese National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, 189 Guo Shou Jing Road, Shanghai 201203, China. fjnan@mail.shcnc.ac.cn

PMID: 18663717
DOI: 10.1002/cmdc.200800136

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemical synthesis*
Antiviral Agents / chemistry
Antiviral Agents / pharmacology*
Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
Bridged Bicyclo Compounds, Heterocyclic / chemistry
Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
Drug Design*
Hepatitis B virus / drug effects*
Microbial Sensitivity Tests
Molecular Structure
Small Molecule Libraries
Stereoisomerism
Structure-Activity Relationship
Thiazoles / chemical synthesis
Thiazoles / chemistry
Thiazoles / pharmacology
Viral Nonstructural Proteins / drug effects
Virus Replication / drug effects

Substances

Antiviral Agents
Bridged Bicyclo Compounds, Heterocyclic
Small Molecule Libraries
Thiazoles
Viral Nonstructural Proteins