Post-Soviet Russia experiences among the world's highest prevalence of alcohol-related problems, which contributes to high mortality rates in this region. Reduction in alcohol-related problems in Russia can have strong effects on mortality decline. This article considers the plausibility of application of general principles of alcohol policy translated in the Russian Federation. We conclude that alcohol policy approaches could be implemented in the same ways as they have been in other countries. In addition, there should be special attention to decreasing distilled spirits consumption, illegal alcohol production, nonbeverage alcohol consumption, and enforcement of current governmental regulations.