Abstract
Norneolambertellin (1) was isolated from a mycoparasite Lambertella sp. 1346. Combined analysis of the NMR spectra and chemical shift prediction based on molecular orbital calculation successfully revealed a novel pyrano[3,2-c]chromene-2,5-dione structure, which was further confirmed by X-ray crystallographic analysis. Isotopomer distribution analysis of the sample, prepared under labeling conditions, deduced its biosynthetic pathway.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ascomycota / metabolism*
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Carbon / chemistry
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Chemistry, Pharmaceutical / methods
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Crystallography, X-Ray / methods*
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Drug Design
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Gas Chromatography-Mass Spectrometry / methods
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Ions
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Magnetic Resonance Spectroscopy
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Mass Spectrometry / methods
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Models, Chemical
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Molecular Conformation
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Molecular Structure
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Naphthalenes / chemical synthesis*
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Naphthalenes / chemistry*
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry*
Substances
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Ions
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Naphthalenes
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Spiro Compounds
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Carbon
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lambertellin