Abstract
Ty1 retrotransposons in Saccharomyces cerevisiae are activated by telomere erosion. Ty1-dependent reverse transcription of mRNA from subtelomeric Y' repeats generates chimeric Y'-Ty1 cDNA. Here, we show that Y'-Ty1 cDNA is incorporated at eroding telomeres in the absence of telomerase. Telomeric incorporation of Y'-Ty1 cDNA promotes genome rearrangements.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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DNA, Complementary / genetics
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DNA, Complementary / metabolism*
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DNA, Fungal / genetics
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DNA, Fungal / metabolism
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Gene Rearrangement
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Models, Genetic
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Mutation
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Retroelements / genetics*
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Saccharomyces cerevisiae / enzymology
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Saccharomyces cerevisiae / genetics*
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Saccharomyces cerevisiae / metabolism
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Telomerase / genetics*
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Telomere / metabolism*
Substances
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DNA, Complementary
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DNA, Fungal
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Retroelements
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Telomerase