Abstract
The interplay between mycobacteria and host determines the outcome of infection. After uptake of mycobacteria by macrophages, several possible scenarios may emerge; mycobacteria may be destroyed immediately or there is establishment of persistent infection. This review is focused around mycobacteria-host interactions with reference to Mycobacterium avium subspecies paratuberculosis (MAP) infection and highlights protective mechanisms involved in order to design vaccines and other control strategies.
MeSH terms
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Animals
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Antibodies, Bacterial / biosynthesis
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CD4-Positive T-Lymphocytes / immunology
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Cytokines / immunology
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Cytokines / metabolism*
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Cytotoxicity, Immunologic
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Dendritic Cells / immunology
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Humans
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Macrophages / immunology*
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Macrophages / microbiology
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Mycobacterium avium subsp. paratuberculosis / immunology*
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Mycobacterium avium subsp. paratuberculosis / pathogenicity
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Paratuberculosis / immunology*
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Paratuberculosis / microbiology
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Phagocytosis
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Receptors, Antigen, T-Cell, gamma-delta / immunology
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Receptors, Antigen, T-Cell, gamma-delta / metabolism
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Toll-Like Receptors / immunology*
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Toll-Like Receptors / metabolism
Substances
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Antibodies, Bacterial
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Cytokines
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Receptors, Antigen, T-Cell, gamma-delta
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Toll-Like Receptors