Abstract
Total synthesis of a fungal cyclic peptide, malformin C, recently rediscovered as a G2 checkpoint inhibitor was completed. Our synthesis involved a convergent approach with respect to a linear pentapeptide, cyclization, and oxidative disulfide formation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibiotics, Antineoplastic / antagonists & inhibitors*
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Antibiotics, Antineoplastic / toxicity*
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Bleomycin / antagonists & inhibitors*
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Bleomycin / toxicity*
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Cell Division / drug effects
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Cyclization
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DNA Damage / drug effects
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Disulfides / chemistry
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G2 Phase / drug effects*
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Oxidation-Reduction
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Peptides, Cyclic / chemical synthesis*
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Peptides, Cyclic / pharmacology*
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Infrared
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Spectroscopy, Fourier Transform Infrared
Substances
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Antibiotics, Antineoplastic
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Disulfides
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Indicators and Reagents
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Peptides, Cyclic
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Bleomycin
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malformins